Associate Professor (Computational Pharmacology and Toxicology)

Dr. Muhammad Ishfaq

School of Computer Science and Artificial Intelligence

Huanggang Normal University, Huanggang 43800, Hubei, China

1007 Houde building

Email: muhammad@hgnu.edu.cn

Education

PhD, Basic Veterinary Medicine, Northeast Agricultural University Harbin, China, 2021

MSc, Basic Veterinary Medicine, Northeast Agricultural University Harbin, China, 2018

Doctor of Veterinary Medicine (DVM), The University of Agriculture Peshawar, Pakistan, 2014

Professional Experience

Associate Professor, Computational Pharmacology and Toxicology (2021-present)

Visiting Research Scientist, University of Michigan, Ann Arbor, MI, United States (2024-2025).

Research Interests

Virtual drug screening, high-throughput drug screening, computational methods, chemoinformatics, animal health, conservation medicine, drug repurposing, mechanism of drug action, PK/PD, ADMET properties, developing cellular and animal disease models, transcriptomics, proteomics, metabolomics and identification of therapeutic targets.

Awards

2022 Chutian Scholar Award, Hubei, Huanggang Normal University, Huanggang 438000, China

2018 Outstanding Scholar Award, Northeast Agricultural University, Harbin150030, China

Selected Publications

1        Ishfaq M, Wu Z, Wang J, Li R, Chen C, Li J. Baicalin alleviates Mycoplasma gallisepticum-induced oxidative stress and inflammation via modulating NLRP3 inflammasome-autophagy pathway. Int Immunopharmacol. 2021, 101(Pt B):108250.

2        Ishfaq M, Chen C, Bao J, Zhang W, Wu Z, Wang J, Liu Y, Tian E, Hamid S, Li R, Ding L, Li J. Baicalin ameliorates oxidative stress and apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-κB and Nrf2/HO-1 signaling pathway during Mycoplasma gallisepticum infection. Poult Sci. 2019, 98(12):6296-6310.

3        Ishfaq M, Zhang W, Liu Y, Wang J, Wu Z, Shah SW, Li R, Miao Y, Chen C, Li J. Baicalin attenuated Mycoplasma gallisepticum-induced immune impairment in chicken bursa of fabricius through modulation of autophagy and inhibited inflammation and apoptosis. J Sci Food Agric. 2021, 101(3):880-890. 

4        Ishfaq M, Sun X, Wang H, Li W, Wang X, Cheng P, Li S, Zhang X, Hamid S. Curcumin Successfully Inhibited the Computationally Identified CYP2A6 Enzyme-Mediated Bioactivation of Aflatoxin B1 in Arbor Acres broiler. Front Pharmacol. 2017, 8:143. 

5        Ishfaq M, Shah SZA, Ahmad I, Rahman Z. Multinomial classification of NLRP3 inhibitory compounds based on large scale machine learning approaches. Mol Divers. 2024, 28(4):1849-1868.

6        Bhutto JA, Mubashir T , Tahir MH, Hafsa, Ahmad F, Sayed SRM, El-ansary H, Ishfaq M*. Virtual screening and library enumeration of new hydroxycinnamates based antioxidant compounds: A complete framework. J Saudi Chem Soc, 2023, 27(4):101670.

7        Li J, Qiao Z, Hu W, Zhang W, Shah SWA, Ishfaq M*. Baicalin mitigated Mycoplasma gallisepticum-induced structural damage and attenuated oxidative stress and apoptosis in chicken thymus through the Nrf2/HO-1 defence pathway. Vet Res. 2019, 50(1):83.